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Endometriosis increases ovarian cancer risk February 26, 2012

Posted by patoconnor in cancer, gynecological cancer, ovarian cancer, tubal cancer, uterine cancer, vaginal cancer.
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Endometriosis increases ovarian cancer risk

By Stephen Adams

Thursday February 23 2012

WOMEN who suffer from endometriosis are at more than twice the risk of developing three common forms of ovarian cancer, according to new research.

Celeste Leigh Pearce from the University of Southern CaliforniaLos Angeles, lead author of the study, said the “breakthrough” could lead to screening programmes or risk-reduction surgery for higher-risk women.

She and her team found that endometriosis tripled a woman’s lifetime risk of developing a type called clear cell ovarian cancer, from 1 in 500 to one in 180.

It also more than doubled the risk of two other types, called endometrioid and low-grade serous ovarian cancer, from one in 400 to one in 180.

The US researchers made their conclusions in The Lancet Oncology after looking at data from over 23,000 women, of whom almost 8,000 had invasive ovarian cancer.

Dr Paul Pharoah from Cambridge University said it was “well established” that having endometriosis increased a woman’s lifetime risk of all types of ovarian cancer from about one in 50 to one in 40.

Prof Hani Gabra, director of the Ovarian Cancer Action Research Centre at Imperial College London, described the study as “interesting”.

“However, most women with endometriosis will not go on to develop ovarian cancer,” he added.

“It is important that all women should be aware of the signs and symptoms of ovarian cancer and consult their GP if they are concerned.”

About 10 per cent of women are thought to develop endometriosis, where womb lining tissue develops outside the uterus, although estimates vary. It can cause painful periods, while sex can hurt, and it can reduce fertility too.

– Stephen Adams

In

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HE4–a novel promising serum marker in the diagnosis of ovarian carcinoma. February 18, 2012

Posted by patoconnor in cancer, gynecological cancer, ovarian cancer, tubal cancer, Uncategorized, uterine cancer, vaginal cancer.
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HE4–a novel promising serum marker in the diagnosis of ovarian carcinoma.

Langmár ZNémeth MVleskó GKirály MHornyák LBösze P.

Source

2nd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary. langmarzoltan@hotmail.com

Abstract

Biomarkers have a wide range of applications in the management of several cancers. To date serum markers have been the most extensively used biomarkers in everyday practice but few markers are elevated in preclinical or premalignant disease, limiting their importance for estimating risk or for screening. Human epididymis protein-4 (HE4) is a novel serum marker which is more sensitive in the prediction of risk of ovarian malignancy than CA125 alone in patients with a pelvic mass. HE4 in combination with CA125 appears to be an effective tool for the early detection of recurrence or monitoring the response to therapy. Risk of Ovarian Malignancy Algorithm, utilizing the dual marker combination of HE4 and CA125, can be used to stratify both postmenopausal and premenopausal women into high- and low-risk groups, allowing for an effective triage of women to appropriate institutions for their care. A review of HE4 and its feasibility as a novel diagnostic tool in the management of epithelial ovarian cancer is presented.

PubMed